What if we could grow ours cells in a 3D environment with a total control on their exposure to external stimuli like drugs or biologics and capture a multiplexed secreted cell response in real-time? And work with only few samples without the need to wait for days or weeks to perform the biomarkers assessment, just to gather the right number of samples to avoid wasting time and immuno-assays kits? And without the need to buy a dedicated multiplex system, just using a fluorescence microscope?
That’s why Nanobiose develops SecretCells®, an innovative in vitro platform for the simultaneous evaluation of cytotoxicity and secretion of biomarkers. Easy to use and implement, based on fluorescent readouts, SecretCells® has been developed to allow scientists to perform a better in vitro evaluation of their new drugs on the basis of perfused 3D cell cultures. This enables a perfect control of cells exposure to the tested products in a physiologically more relevant environment, leading to a better selection of compounds at early stages of development.
SecretCells® is a unique combination of a microfluidic biochip harboring two independent wells for cells culture and a removable biosensor for the capture and multiplexed analysis of secreted biomarkers (up to 9 different biomarkers, e.g. TNF-α , IL-1β, IL-2, IFN-γ, …). The microfluidic biochip can be operated with a peristaltic pump, a syringe pump or a pressure controller. The biosensor is revealed with a reagent kit (immuno-staining) and further processed with a fluorescence microscope or a slide scanner.
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Here are some of the advantages of SecretCells® :